Advancing Clinical Trials in Vision and Eyes (ACTIVE)

About us

ACTIVE is located within BRC. Its remit is to increase clinical trial activity in ophthalmology and develop a methodological hub for all aspects of the design, conduct and reporting of trials. This includes research for pioneering world leading gene and stem cell therapies, new drug treatments and novel diagnostic devices for management of visual impairment.

Specific activities focus on research into cost-efficiencies in trial conduct, strategies for improving recruitment and the development of core and patient orientated outcome sets for eye and vision trials.

ACTIVE partnerships

ACTIVE was set up by Mr Richard Wormald (Consultant Ophthalmologist - Moorfields Eye Hospital and Coordinating Editor - Cochrane Eyes and Vision Group) and Dr Catey Bunce (Reader of Medical Statistics - King's College London and Statistical Editor - Cochrane Eyes and Vision Group).

The Centre links with the Ophthalmic Statistics Group which has an aim to ‘raise the standards of statistics in ophthalmic research’; and is formally linked with the Cochrane Eyes and Vision Group and the newly established UCL Clinical Trials Unit (UCL- CTU).

The Centre’s services are available to researchers, throughout Moorfields, UCLPartners and other academic and industrial partners.


ACTIVE helps research teams throughout the country design clinical trials safely and to a high scientific standard, offering a range of services to help ensure the results are accurate and credible, including:

  • Framing the research question

  • Design

  • Protocol Development

  • Statistical Guidance

  • PPI

  • Methodological Research

ACTIVE offers comprehensive support to trials across all ophthalmic disease areas in MEH/UCL that are funded by NIHR HTA, NIHR EME, NIHR SDO, NIHR PHR, NIHR HSR and NIHR RfPB. Other trials may be accepted onto the portfolio for support on a case by case basis.

Information ​​for researchers

​​Information for patients and the public

ACTIVE is not involved in the recruitment of patients into clinical studies and cannot offer advise on how to take part in a clinical study:

  • For information on clinical studies currently being conducted at Moorfields Eye Hospital and how to find out more please see their Participating in Research webpages

  • For information on clinical trials in the UK and elsewhere please visit the NHS Choices Clinical Trials webpages.

ACTIVE Spoke and Hub Model

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